B cell-intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice.

Michelle S J Lee, Takeshi Inoue, Wataru Ise, Julia Matsuo-Dapaah, James B Wing, Burcu Temizoz, Kouji Kobiyama, Tomoya Hayashi, Ashwini Patil, Shimon Sakaguchi, A Katharina Simon, Jelena S Bezbradica, Satoru Nagatoishi, Kouhei Tsumoto, Jun-Ichiro Inoue, Shizuo Akira, Tomohiro Kurosaki, Ken J Ishii, Cevayir Coban

The Journal of experimental medicine　Vol. 219　No. 2　2022年2月7日　研究論文（学術雑誌）

Exit from germinal center to become quiescent memory B cells depends on metabolic reprograming and provision of a survival signal.

Takeshi Inoue, Ryo Shinnakasu, Chie Kawai, Wataru Ise, Eiryo Kawakami, Nicolas Sax, Toshihiko Oki, Toshio Kitamura, Kazuo Yamashita, Hidehiro Fukuyama, Tomohiro Kurosaki

The Journal of experimental medicine　Vol. 218　No. 1　2021年1月4日　研究論文（学術雑誌）

Publisher Correction: Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity.

Shinya Tanaka, Wataru Ise, Takeshi Inoue, Ayako Ito, Chisato Ono, Yoshihito Shima, Shuhei Sakakibara, Manabu Nakayama, Kentaro Fujii, Ikuo Miura, Jafar Sharif, Haruhiko Koseki, Pandelakis A Koni, Indu Raman, Quan-Zhen Li, Masato Kubo, Katsunori Fujiki, Ryuichiro Nakato, Katsuhiko Shirahige, Hiromitsu Araki, Fumihito Miura, Takashi Ito, Eiryo Kawakami, Yoshihiro Baba, Tomohiro Kurosaki

Nature immunology　Vol. 21　No. 12　p. 1611-1612　2020年12月

Tet DNA demethylase is required for plasma cell differentiation by controlling expression levels of IRF4

Kentaro Fujii, Shinya Tanaka, Takanori Hasegawa, Masashi Narazaki, Atsushi Kumanogoh, Haruhiko Koseki, Tomohiro Kurosaki, Wataru Ise

International Immunology　Vol. 32　No. 10　p. 683-690　2020年9月30日　研究論文（学術雑誌）

Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity.

Shinya Tanaka, Wataru Ise, Takeshi Inoue, Ayako Ito, Chisato Ono, Yoshihito Shima, Shuhei Sakakibara, Manabu Nakayama, Kentaro Fujii, Ikuo Miura, Jafar Sharif, Haruhiko Koseki, Pandelakis A Koni, Indu Raman, Quan-Zhen Li, Masato Kubo, Katsunori Fujiki, Ryuichiro Nakato, Katsuhiko Shirahige, Hiromitsu Araki, Fumihito Miura, Takashi Ito, Eiryo Kawakami, Yoshihiro Baba, Tomohiro Kurosaki

Nature immunology　Vol. 21　No. 8　p. 950-961　2020年8月　研究論文（学術雑誌）

B cell-intrinsic MyD88 signaling controls IFN-γ-mediated early IgG2c class switching in mice in response to a particulate adjuvant.

Michelle Sue Jann Lee, Yayoi Natsume-Kitatani, Burcu Temizoz, Yukiko Fujita, Aki Konishi, Kyoko Matsuda, Yoshikatsu Igari, Toshihiro Tsukui, Kouji Kobiyama, Etsushi Kuroda, Motoyasu Onishi, Thomas Marichal, Wataru Ise, Takeshi Inoue, Tomohiro Kurosaki, Kenji Mizuguchi, Shizuo Akira, Ken J Ishii, Cevayir Coban

European journal of immunology　Vol. 49　No. 9　p. 1433-1440　2019年9月　研究論文（学術雑誌）

Heme ameliorates dextran sodium sulfate-induced colitis through providing intestinal macrophages with noninflammatory profiles

Hisako Kayama, Masako Kohyama, Daisuke Okuzaki, Daisuke Motooka, Soumik Barman, Ryu Okumura, Masato Muneta, Katsuaki Hoshino, Izumi Sasaki, Wataru Ise, Hiroshi Matsuno, Junichi Nishimura, Tomohiro Kurosaki, Shota Nakamura, Hisashi Arase, Tsuneyasu Kaisho, Kiyoshi Takeda

Proceedings of the National Academy of Sciences　Vol. 115　No. 33　p. 8418-8423　2018年8月14日　研究論文（学術雑誌）

T Follicular Helper Cell-Germinal Center B Cell Interaction Strength Regulates Entry into Plasma Cell or Recycling Germinal Center Cell Fate.

Wataru Ise, Kentaro Fujii, Katsuyuki Shiroguchi, Ayako Ito, Kohei Kometani, Kiyoshi Takeda, Eiryo Kawakami, Kazuo Yamashita, Kazuhiro Suzuki, Takaharu Okada, Tomohiro Kurosaki

Immunity　Vol. 48　No. 4　p. 702-715　2018年4月17日　研究論文（学術雑誌）

The transcription factor Foxo1 controls germinal center B cell proliferation in response to T cell help.

Takeshi Inoue, Ryo Shinnakasu, Wataru Ise, Chie Kawai, Takeshi Egawa, Tomohiro Kurosaki

The Journal of experimental medicine　Vol. 214　No. 4　p. 1181-1198　2017年4月3日　研究論文（学術雑誌）

Inhaled Fine Particles Induce Alveolar Macrophage Death and Interleukin-1α Release to Promote Inducible Bronchus-Associated Lymphoid Tissue Formation.

Etsushi Kuroda, Koji Ozasa, Burcu Temizoz, Keiichi Ohata, Christine X Koo, Tomohiro Kanuma, Takato Kusakabe, Shingo Kobari, Masanori Horie, Yasuo Morimoto, Saeko Nakajima, Kenji Kabashima, Steven F Ziegler, Yoichiro Iwakura, Wataru Ise, Tomohiro Kurosaki, Takahiro Nagatake, Jun Kunisawa, Naoki Takemura, Satoshi Uematsu, Masayuki Hayashi, Taiki Aoshi, Kouji Kobiyama, Cevayir Coban, Ken J Ishii

Immunity　Vol. 45　No. 6　p. 1299-1310　2016年12月20日　研究論文（学術雑誌）

Bach2-Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop.

Makoto Kuwahara, Wataru Ise, Mizuki Ochi, Junpei Suzuki, Kohei Kometani, Saho Maruyama, Maya Izumoto, Akira Matsumoto, Nobuaki Takemori, Ayako Takemori, Kenta Shinoda, Toshinori Nakayama, Osamu Ohara, Masaki Yasukawa, Tatsuya Sawasaki, Tomohiro Kurosaki, Masakatsu Yamashita

Nature communications　Vol. 7　p. 12596-12596　2016年9月1日　研究論文（学術雑誌）

Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis.

Yuhsuke Ohmi, Wataru Ise, Akira Harazono, Daisuke Takakura, Hidehiro Fukuyama, Yoshihiro Baba, Masashi Narazaki, Hirofumi Shoda, Nobunori Takahashi, Yuki Ohkawa, Shuting Ji, Fumihiro Sugiyama, Keishi Fujio, Atsushi Kumanogoh, Kazuhiko Yamamoto, Nana Kawasaki, Tomohiro Kurosaki, Yoshimasa Takahashi, Koichi Furukawa

Nature communications　Vol. 7　p. 11205-11205　2016年4月5日　研究論文（学術雑誌）

Hydroxypropyl-β-cyclodextrin spikes local inflammation that induces Th2 cell and T follicular helper cell responses to the coadministered antigen.

Motoyasu Onishi, Koji Ozasa, Kouji Kobiyama, Keiichi Ohata, Mitsutaka Kitano, Keiichi Taniguchi, Tomoyuki Homma, Masanori Kobayashi, Akihiko Sato, Yuko Katakai, Yasuhiro Yasutomi, Edward Wijaya, Yoshinobu Igarashi, Noriyuki Nakatsu, Wataru Ise, Takeshi Inoue, Hiroshi Yamada, Alexis Vandenbon, Daron M Standley, Tomohiro Kurosaki, Cevayir Coban, Taiki Aoshi, Etsushi Kuroda, Ken J Ishii

Journal of immunology　Vol. 194　No. 6　p. 2673-82　2015年3月15日　研究論文（学術雑誌）

Regulatory T cells control antigen-specific expansion of Tfh cell number and humoral immune responses via the coreceptor CTLA-4.

James Badger Wing, Wataru Ise, Tomohiro Kurosaki, Shimon Sakaguchi

Immunity　Vol. 41　No. 6　p. 1013-25　2014年12月18日　研究論文（学術雑誌）

Memory B cells contribute to rapid Bcl6 expression by memory follicular helper T cells

Wataru Ise, Takeshi Inoue, James B. McLachlan, Kohei Kometani, Masato Kubo, Takaharu Okada, Tomohiro Kurosaki

Proceedings of the National Academy of Sciences　Vol. 111　No. 32　p. 11792-11797　2014年8月12日　研究論文（学術雑誌）

The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells.

Wataru Ise, Masako Kohyama, Barbara U Schraml, Tingting Zhang, Bjoern Schwer, Uttiya Basu, Frederick W Alt, Jun Tang, Eugene M Oltz, Theresa L Murphy, Kenneth M Murphy

Nature immunology　Vol. 12　No. 6　p. 536-43　2011年6月　研究論文（学術雑誌）

Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells.

Brian T Edelson, Wumesh KC, Richard Juang, Masako Kohyama, Loralyn A Benoit, Paul A Klekotka, Clara Moon, Jörn C Albring, Wataru Ise, Drew G Michael, Deepta Bhattacharya, Thaddeus S Stappenbeck, Michael J Holtzman, Sun-Sang J Sung, Theresa L Murphy, Kai Hildner, Kenneth M Murphy

The Journal of experimental medicine　Vol. 207　No. 4　p. 823-36　2010年4月12日　研究論文（学術雑誌）

CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms.

Wataru Ise, Masako Kohyama, Katherine M Nutsch, Hyang Mi Lee, Anish Suri, Emil R Unanue, Theresa L Murphy, Kenneth M Murphy

Nature immunology　Vol. 11　No. 2　p. 129-35　2010年2月　研究論文（学術雑誌）

The AP-1 transcription factor Batf controls T(H)17 differentiation.

Barbara U Schraml, Kai Hildner, Wataru Ise, Wan-Ling Lee, Whitney A-E Smith, Ben Solomon, Gurmukh Sahota, Julia Sim, Ryuta Mukasa, Saso Cemerski, Robin D Hatton, Gary D Stormo, Casey T Weaver, John H Russell, Theresa L Murphy, Kenneth M Murphy

Nature　Vol. 460　No. 7253　p. 405-9　2009年7月16日　研究論文（学術雑誌）

Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis.

Masako Kohyama, Wataru Ise, Brian T Edelson, Peter R Wilker, Kai Hildner, Carlo Mejia, William A Frazier, Theresa L Murphy, Kenneth M Murphy

Nature　Vol. 457　No. 7227　p. 318-21　2009年1月15日　研究論文（学術雑誌）

Lactobacillus acidophilus strain L-92 induces apoptosis of antigen-stimulated T cells by modulating dendritic cell function

Hiroki Kanzato, Shigeru Fujiwara, Wataru Ise, Shuichi Kaminogawa, Ryuichiro Sato, Satoshi Hachimura

Immunobiology　Vol. 213　No. 5　p. 399-408　2008年6月　研究論文（学術雑誌）

Orally Tolerized T Cells Can Form Conjugates with APCs but Are Defective in Immunological Synapse Formation

Wataru Ise, Kentaro Nakamura, Nobuko Shimizu, Hirofumi Goto, Kenichiro Fujimoto, Shuichi Kaminogawa, Satoshi Hachimura

The Journal of Immunology　Vol. 175　No. 2　p. 829-838　2005年7月15日　研究論文（学術雑誌）

Ca ²⁺ signaling down-regulates TGF-β1 gene expression in CD4 ⁺ T cells

Masako Kohyama, Yasuhito Yasogi, Naoko Nakano, Wataru Ise, Shuichi Kaminogawa, Nobumichi Hozumi

Biochemical and Biophysical Research Communications　Vol. 327　No. 2　p. 494-499　2005年2月11日　研究論文（学術雑誌）

T-cell receptor antagonist modifies cytokine secretion profile of naive CD4+ T cells and their differentiation into type-1 and type-2 helper T cells

Rumi Takato-Kaji, Mamoru Totsuka, Wataru Ise, Megumi Nishikawa, Satoshi Hachimura, Shuichi Kaminogawa

Immunology Letters　Vol. 96　No. 1　p. 39-45　2005年1月　研究論文（学術雑誌）

Hyporesponsiveness of CD4 T Cells Induced in Oral Tolerance Is Maintained by Selective Impairment in the TCR-Induced Calcium/NFAT Signaling Pathway Resulting from Caspase Activation

SATOSHI HACHIMURA, TOMOHIRO KAJI, KAZUMI ASAI, WATARU ISE, TOSHINORI NAKAYAMA, SHUICHI KAMINOGAWA

Annals of the New York Academy of Sciences　Vol. 1029　No. 1　p. 344-345　2004年12月　研究論文（学術雑誌）

Dendritic Cells from Spleen, Mesenteric Lymph Node and Peyer's Patch Can Induce the Production of Both IL-4 and IFN-gamma from Primary Cultures of Naive CD4(+) T Cells in a Dose-Dependent Manner.

Masanobu Hibi, Satoshi Hachimura, Wataru Ise, Ayuko Sato, Tadashi Yoshida, Tsuyoshi Takayama, Kastumi Sasaki, Takashi Senga, Shuichi Hashizume, Mamoru Totsuka, Shuichi Kaminogawa

Cytotechnology　Vol. 43　No. 1-3　p. 49-55　2003年11月　研究論文（学術雑誌）

Identification of the genes specifically expressed in orally tolerized T cells.

Takayasu Gotoh, Wataru Ise, Atsuko Nonaka, Shuichi Hamaguchi, Satoshi Hachimura, Shuichi Kaminogawa

Cytotechnology　Vol. 43　No. 1-3　p. 73-80　2003年11月　研究論文（学術雑誌）

Interleukin 12 and CD86 Regulate Th1 and Th2 Development Induced by a Range of Antigen Doses Presented by Peyer's Patch and Spleen Cells.

Tadashi Yoshida, Satoshi Hachimura, Mina Ishimori, Wataru Ise, Mamoru Totsuka, Akio Ametani, Shuichi Kaminogawa

Cytotechnology　Vol. 43　No. 1-3　p. 81-8　2003年11月　研究論文（学術雑誌）

Proteome analysis reveals caspase activation in hyporesponsive CD4 T lymphocytes induced in vivo by the oral administration of antigen.

Tomohiro Kaji, Satoshi Hachimura, Wataru Ise, Shuichi Kaminogawa

The Journal of biological chemistry　Vol. 278　No. 30　p. 27836-43　2003年7月25日　研究論文（学術雑誌）

Naive CD4+ T cells exhibit distinct expression patterns of cytokines and cell surface molecules on their primary responses to varying doses of antigen.

Wataru Ise, Mamoru Totsuka, Yoshitaka Sogawa, Akio Ametani, Satoshi Hachimura, Takehito Sato, Yoshihiro Kumagai, Sonoko Habu, Shuichi Kaminogawa

Journal of immunology　Vol. 168　No. 7　p. 3242-50　2002年4月1日　研究論文（学術雑誌）

Antigen Presentation by Peyer's Patch Cells Can Induce both Th1- and Th2-type Responses Depending on Antigen Dosage, but a Different Cytokine Response Pattern from That of Spleen Cells

Tadashi YOSHIDA, Satoshi HACHIMURA, Mina ISHIMORI, Fumitaka KINUGASA, Wataru ISE, Mamoru TOTSUKA, Akio AMETANI, Shuichi KAMINOGAWA

Bioscience, Biotechnology, and Biochemistry　Vol. 66　No. 5　p. 963-969　2002年1月　研究論文（学術雑誌）

Primary response of naive CD4⁺ T cells to amino acid-substituted analogs of an antigenic peptide can show distinct activation patterns: Th1- and Th2-type cytokine secretion, and helper activity for antibody production without apparent cytokine secretion

Wataru Ise, Mamoru Totsuka, Rumi Takato, Satoshi Hachimura, Takehito Sato, Akio Ametani, Yoshihiro Kumagai, Sonoko Habu, Shuichi Kaminogawa

FEBS Letters　Vol. 465　No. 1　p. 28-33　2000年1月7日　研究論文（学術雑誌）

Determinant analysis of IgE and IgG4 antibodies and T cells specific for bovine αs1-casein from the same patients allergic to cow's milk: Existence of αs1-casein–specific B cells and T cells characteristic in cow's-milk allergy

Haruyo Nakajima-Adachi, Satoshi Hachimura, Wataru Ise, Kiri Honma, Shinya Nishiwaki, Maiko Hirota, Naoki Shimojo, Toshiyuki Katsuki, Akio Ametani, Yoichi Kohno

Journal of Allergy and Clinical Immunology　Vol. 101　No. 5　p. 660-671　1998年5月　研究論文（学術雑誌）